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-, Bradley, Mike. O'Donnell, Paul · 2025 · E-Book · Fakultas Ilmu Kesehatan, S1 Fisioterapi

- Abstract (EN): -

Adenikheir, Annisa. Wulandari, Tiara · 2025 · manuskrip · Fakultas Ilmu Kesehatan, D3 Fisioterapi

Kelincahan merupakan salah satu elemen penting komponen bimotorik tubuh yang berperan dalam olahraga. Kelincahan merupakan kemampuan tubuh untuk merubah arah secapat mungkin, arah yang dimaksud adalah depan, belakang, kanan, dan kiri. Latihan (SAQ) yang dianggap efektif mampu meningkatkan kemampuan dalam melakukan perubahan arah, meningkatkan akselerasi, dan efektif meningkatkan deselerasi dengan cepat sehingga atlet mampu bermain bola basket dengan cara berlari cepat, efektif, dan dilakukan secara berulang. Penelitian ini bertujuan untuk mengetahui Pengaruh Pemberian Latihan Speed Agility Quickness (SAQ) Terhadap Kelincahan Pada Pemain Bola Basket Di Club Basket Halilintar Bukittinggi Tahun 2024. Penelitian ini dilakukan pada Bulan Februari. Metode yang digunakan dalam penelitian ini adalah sebanyak 30 orang dengan sampel sebanyak 14 orang. Penelitian ini dilakukan selama 4 minggu. Hasil dari 14 orang sampel memiliki rata-rata kelincahan sebelum pemberian intervensi 14.26 dengan nilai minimum 15.56 dan nilai maksimum 13.33. Dan rata-rata setelah pemberian intervensi 13.6821 dengan nilai minimum 12.71 dan nilai maksimum 14.82 di club basket halilintar Bukittinggi tahun 2024. Pengaruh intervensi menunjukkan adanya penagaruh ditandai dengan nilai p= 0,001 < ( 0,05 ) artinya adanya pengaruh latihan Speed Agility Quickness (SAQ) terhadap peningkatan kelincahan pemain bola basket di club basket halilintar Bukittinggi. Abstract (EN): Agility is one of the important elements of the bimotor component of the body that plays a role in sports. Agility is the body's ability to change direction as quickly as possible, the directions in question are front, back, right, and left. Training (SAQ) is considered effective in increasing the ability to change direction, increase acceleration, and effectively increase deceleration quickly so that athletes are able to play basketball by running fast, effectively, and repeatedly. This study aims to determine the effect of giving Speed Agility Quickness (SAQ) training on agility in basketball players at the Halilintar Bukittinggi Basketball Club in 2024. This research was conducted from February . The method used in this research is Quasi Experiment with one group pretest-posttest method. The total patient population was 30 people with a sample of 14 people. This study was conducted for 4 weeks. The results of the 14 samples had an average agility before giving the intervention of 14.26 with a minimum value of 15.56 and a maximum value of 13.33. And the average after giving intervention 13.6821 with a minimum value of 12.71 and a maximum value of 14.82 at the halilintar Bukittinggi Basketball club in 2024. The effect of the intervention shows that there is an influence characterized by a p value = 0.001 < (0.05), meaning that there is an effect of Speed Agility Quickness (SAQ) training on increasing the agility of soccer players.

Sri Gusriyani, Devita Sepriani Utami · 2025 · Skripsi · Fakultas Ilmu Kesehatan, S1 Farmasi

Sistem imun tubuh memiliki peran penting dalam mempertahankan diri dari infeksi, salah satunya melalui aktivitas sel T sitotoksik (CD8+). Daun alpukat (Persea americana Mill.) diketahui mengandung flavonoid, alkaloid, saponin, serta fenol yang berpotensi sebagai imunomodulator. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian fraksi n-heksan daun alpukat terhadap kadar CD8 tikus putih (Rattus norvegicus). Penelitian eksperimental dilakukan dengan rancangan pre-post only control group menggunakan tiga kelompok perlakuan, yaitu kontrol, fraksi n-heksan daun alpukat, dan pembanding stimuno. Fraksi diberikan secara oral selama 14 hari dengan dosis 600 mg/200 g BB. Kadar CD8 diukur menggunakan metode ELISA sebelum dan sesudah perlakuan. Hasil analisis menunjukkan adanya peningkatan kadar CD8 pada kelompok perlakuan dibandingkan kontrol. Kesimpulannya, fraksi n-heksan daun alpukat berpotensi sebagai imunostimulan alami dan dapat mendukung pengembangan fitofarmaka berbasis bahan alam lokal. Abstract (EN): The immune system plays a vital role in defending the body against infections, one of which involves the activity of cytotoxic T cells (CD8+). Avocado leaves ( Persea americana Mill.) are known to contain flavonoids, alkaloids, saponins, and phenolic compounds that have potential as immunomodulators. This study aimed to determine the effect of the n- hexane fraction of avocado leaves on CD8 levels in white rats ( Rattus norvegicus ). An experimental study was conducted using a pre-post only control group design with three treatment groups: control, n -hexane fraction of avocado leaves, and the positive control Stimuno ®. The fraction was administered orally for 14 days at a dose of 600 mg/200 g body weight. CD8 levels were measured using the ELISA method before and after treatment. The results showed an increase in CD8 levels in the treatment group compared to the control. In conclusion, the n -hexane fraction of avocado leaves exhibits potential as a natural immunostimulant and may contribute to the development of herbal-based immunomodulatory phytopharmaceuticals.

Evi Hasnita, Afrima Rozalia · 2025 · Skripsi · Fakultas Ilmu Kesehatan, S1 Kebidanan

Penelitian ini menginvestigasi pengaruh model komunikasi antar pribadi yang diterapkan oleh bidan terhadap tingkat kepuasan ibu hamil yang menerima pelayanan Antenatal Care (ANC) di Puskesmas Sungai Dareh, Kabupaten Dharmasraya. Latar belakang penelitian ini didasari oleh pentingnya ANC dalam upaya preventif penurunan risiko kehamilan dan persalinan, serta peran vital komunikasi yang efektif antara bidan dan ibu hamil dalam meningkatkan kepuasan pasien. Data dari WHO menunjukkan bahwa angka kematian ibu (AKI) masih menjadi perhatian global, khususnya di negara berkembang, yang dapat dicegah melalui pelayanan kesehatan yang berkualitas. Di Indonesia, cakupan ANC masih perlu ditingkatkan, dan di Kabupaten Dharmasraya, hasil pemeriksaan ANC berkualitas masih tergolong rendah. Penelitian ini menyoroti bahwa kepuasan pasien merupakan bagian integral dari jaminan mutu layanan kesehatan, termasuk sikap dan kelancaran komunikasi antara petugas kesehatan dan pasien. Komunikasi yang baik dapat membangun rasa saling percaya antara bidan dan ibu hamil, yang pada gilirannya dapat meningkatkan kepuasan dan mendorong kunjungan ulang. Hasil wawancara pendahuluan menunjukkan adanya variasi dalam persepsi ibu hamil terhadap komunikasi yang diberikan oleh bidan di Puskesmas Sungai Dareh. Oleh karena itu, penelitian ini bertujuan untuk mengeksplorasi lebih lanjut bagaimana model komunikasi antar pribadi memengaruhi kepuasan ibu hamil, dengan harapan dapat memberikan wawasan berharga untuk pengembangan praktik pelayanan kesehatan dan peningkatan kualitas komunikasi antara bidan dan ibu hamil di masa depan. Penelitian ini dilakukan di Puskesmas Sungai Dareh pada bulan Oktober-November 2024, dengan populasi ibu hamil yang mendapatkan pelayanan ANC. Abstract (EN): This research investigates the influence of the interpersonal communication model applied by midwives on the satisfaction level of pregnant women who receive Antenatal Care (ANC) services at the Sungai Dareh Health Centre, Dharmasraya Regency. The background of this study is based on the importance of ANC in preventive efforts to reduce the risk of pregnancy and labour, as well as the vital role of effective communication between midwives and pregnant women in increasing patient satisfaction. Data from WHO shows that the maternal mortality rate (AKI) is still a global concern, especially in developing countries, which can be prevented through quality health services. In Indonesia, ANC coverage still needs to be increased, and in Dharmasraya Regency, the results of quality ANC examination are still relatively low. This research highlights that patient satisfaction is an integral part of health service quality assurance, including attitude and smooth communication between health workers and patients. Good communication can build mutual trust between midwives and pregnant women, which in turn can increase satisfaction and encourage repeat visits. The results of the preliminary interview showed that there was a variation in the perception of pregnant women towards the communication given by midwives at the Dareh River Health Centre. Therefore, this study aims to further explore how interpersonal communication models affect the satisfaction of pregnant women, with the hope of providing valuable insights for the development of health care practises and improving the quality of communication between midwives and pregnant women in the future. This research was conducted at the Sungai Dareh Health Centre in October-November 2024, with the population of pregnant women receiving ANC services

Evi Hasnita, Nadiatul Khoiriyah · 2025 · Skripsi · Fakultas Ilmu Kesehatan, S1 Farmasi

Drug Related Problems (DRPs) merupakan permasalahan terkait obat yang dapat memengaruhi efektivitas dan keamanan terapi, terutama pada pasien hipertensi yang sering menjalani pengobatan jangka panjang dengan polifarmasi. Penelitian ini bertujuan mengevaluasi kejadian DRPs serta hubungannya dengan keberhasilan terapi pada pasien hipertensi rawat jalan di RS Ibnu Sina Bukittinggi tahun 2024. Desain penelitian yang digunakan adalah cross-sectional retrospektif dengan total 41 pasien sebagai sampel. Identifikasi DRPs dilakukan menggunakan kriteria ASHP dan PCNE, sedangkan keberhasilan terapi dinilai berdasarkan pencapaian target tekanan darah menurut JNC 8. Data dianalisis secara deskriptif dan uji Chi-Square dengan tingkat signifikansi p Abstract (EN): Drug Related Problems (DRPs) are issues related to drug therapy that can hinder the achievement of optimal therapeutic outcomes. Hypertension patients are considered a high-risk group for DRPs due to the chronic nature of treatment and the potential for polypharmacy. Therefore, evaluating DRPs plays a crucial role in supporting successful hypertension management. This study aimed to evaluate the occurrence of DRPs and analyze their correlation with therapeutic success in outpatient hypertension patients at Ibnu Sina Hospital, Bukittinggi, in 2024. The research was an analytical descriptive study with a retrospective cross-sectional design. The sample consisted of 41 outpatient hypertension patients who met the inclusion criteria, selected using total sampling. Data were collected from medical records and analyzed using the Chi-Square test to assess the relationship between DRPs and therapeutic outcomes. Out of the 41 patients, 22 patients (53.7%) experienced DRPs. The most common types of DRPs identified were drug interactions (36.6%) and inappropriate drug selection (22%). Therapeutic success was achieved in 24 patients (58.5%). The Chi-Square test results indicated a significant correlation between DRPs and therapeutic success (p = 0.000). Conclusion: There is a significant relationship between the occurrence of DRPs and therapeutic success in hypertension patients. Routine identification and evaluation of DRPs are essential to improve therapy quality and prevent treatment failure.

Harry Ade Saputra, Muthia Arifah · 2025 · Skripsi · Fakultas Ilmu Kesehatan, S1 Farmasi

Daun gambir (Uncaria gambir (W. Hunter) Roxb) diketahui mengandung katekin sebagai senyawa utama yang berpotensi sebagai antiinflamasi, antioksidan, antibakteri, antitumor, dan antivirus. Penelitian ini bertujuan mengidentifikasi metabolit sekunder pada ekstrak dan fraksi daun gambir melalui skrining fitokimia dan LC-HRMS serta mengevaluasi aktivitas antiinflamasi menggunakan metode stabilisasi membran HRBC (Human Red Blood Cell). Ekstraksi dilakukan dengan maserasi menggunakan pelarut etanol dan air, sedangkan fraksinasi menggunakan etil asetat, n-heksana, dan air. Hasil skrining fitokimia menunjukkan ekstrak etanol mengandung alkaloid, flavonoid, tanin, saponin, steroid, dan fenol; ekstrak air mengandung alkaloid, flavonoid, tanin, fenol, dan terpenoid; fraksi n-heksana mengandung flavonoid, tanin, steroid, dan fenol; fraksi etil asetat mengandung alkaloid, flavonoid, saponin, steroid, dan fenol; serta fraksi air mengandung alkaloid, flavonoid, tanin, saponin, steroid, dan fenol. Uji antiinflamasi menunjukkan nilai IC50 berturut- turut: natrium diklofenak 470,54 ppm, ekstrak etanol 428,88 ppm, ekstrak air 418,54 ppm, fraksi n-heksana 473,71 ppm, fraksi etil asetat 400,81 ppm, dan fraksi air 464,39 ppm. Fraksi etil asetat memiliki potensi terbaik dengan nilai IC50 terendah dibandingkan ekstrak maupun fraksi lainnya. Dengan demikian, daun gambir berpotensi dikembangkan sebagai agen antiinflamasi alami. Abstract (EN): Gambir Leaves (Uncaria gambir (W. Hunter) Roxb) are known to contain catechins as the main compound, which have potential anti-inflammatory, antioxidant, antibacterial, antitumor, and antiviral activities. This study aims to identify secondary metabolites in the extracts and fractions of gambir leaves through phytochemical screening and LC-HRMS analysis, as well as to evaluate their anti-inflammatory activity using the Human Red Blood Cell (HRBC) membrane stabilization method. Extraction was carried out by maceration using ethanol and water solvents, while fractionation was performed using ethyl acetate, n-hexane, and water. Phytochemical screening results showed that the ethanol extract contained alkaloids, flavonoids, tannins, saponins, steroids, and phenols; the water extract contained alkaloids, flavonoids, tannins, phenols, and terpenoids; the n-hexane fraction contained flavonoids, tannins, steroids, and phenols; the ethyl acetate fraction contained alkaloids, flavonoids, saponins, steroids, and phenols; and the water fraction contained alkaloids, flavonoids, tannins, saponins, steroids, and phenols. The anti-inflammatory assay showed IC₅₀ values as follows: diclofenac sodium 470.54 ppm, ethanol extract 428.88 ppm, water extract 418.54 ppm, n-hexane fraction 473.71 ppm, ethyl acetate fraction 400.81 ppm, and water fraction 464.39 ppm. Among all samples, the ethyl acetate fraction exhibited the best potential with the lowest IC₅₀ value. Therefore, gambir leaves have the potential to be developed as a natural anti-inflammatory agent.

Yulia Yesti, Muhammad Yassin Fajri · 2025 · Skripsi · Fakultas Ilmu Kesehatan, S1 Farmasi

Beras hitam (Oryza sativa L. indica) merupakan salah satu komoditas pangan lokal yang kaya metabolit sekunder, terutama antosianin, flavonoid, alkaloid, dan senyawa fenolik yang berpotensi sebagai sumber antioksidan alami. Antioksidan berperan penting dalam menetralisir radikal bebas yang dapat memicu stres oksidatif, sehingga berhubungan dengan berbagai penyakit degeneratif seperti kanker, diabetes, dan gangguan kardiovaskular. Penelitian ini bertujuan mengetahui aktivitas antioksidan dari ekstrak etanol beras hitam serta fraksinya (n-heksana, etil asetat, dan air) menggunakan metode penangkapan radikal bebas hidrogen peroksida (H2O2) dengan vitamin C sebagai kontrol positif. Simplisia beras hitam diekstraksi menggunakan pelarut etanol 96% melalui metode maserasi, kemudian difraksinasi bertingkat menggunakan n-heksana, etil asetat, dan air. Selanjutnya dilakukan skrining fitokimia untuk mengidentifikasi golongan metabolit sekunder, serta uji aktivitas antioksidan dengan pengukuran persen inhibisi dan nilai IC50 yang dianalisis secara komparatif antar fraksi. Hasil penelitian menunjukkan bahwa masing-masing fraksi memiliki kandungan metabolit sekunder berbeda, di mana fraksi n-heksana cenderung mengandung alkaloid dan terpenoid, sedangkan fraksi etil asetat kaya akan flavonoid dan fenolik. Aktivitas antioksidan tertinggi ditunjukkan oleh fraksi etil asetat dengan nilai IC50 mendekati vitamin C, sementara fraksi n-heksana memiliki aktivitas paling rendah. Dengan demikian, dapat disimpulkan bahwa beras hitam berpotensi dikembangkan sebagai bahan fitofarmaka sumber antioksidan, khususnya melalui pemanfaatan fraksi etil asetat, dan hasil penelitian ini diharapkan memberikan kontribusi ilmiah bagi pengembangan obat tradisional berbasis tanaman sekaligus mendorong pemanfaatan sumber daya alam lokal. Abstract (EN): Black rice (Oryza sativa L. indica) is a local food commodity rich in secondary metabolites, especially anthocyanins, flavonoids, alkaloids, and phenolic compounds that have the potential as a source of natural antioxidants. Antioxidants play an important role in neutralizing free radicals that can trigger oxidative stress, thus being associated with various degenerative diseases such as cancer, diabetes, and cardiovascular disorders. This study aims to determine the antioxidant activity of ethanol extract of black rice and its fractions (n-hexane, ethyl acetate, and water) using the hydrogen peroxide (H2O2) free radical scavenging method with vitamin C as a positive control. Black rice simplicia was extracted using 96% ethanol solvent through the maceration method, then fractionated in stages using n-hexane, ethyl acetate, and water. Furthermore, phytochemical screening was carried out to identify secondary metabolite groups, as well as antioxidant activity testing by measuring the percentage of inhibition and IC50 values which were analyzed comparatively between fractions. The results showed that each fraction contained different secondary metabolites, where the n-hexane fraction tended to contain alkaloids and terpenoids, while the ethyl acetate fraction was rich in flavonoids and phenolics. The highest antioxidant activity was shown by the ethyl acetate fraction with an IC50 value close to vitamin C, while the n-hexane fraction had the lowest activity. Thus, it can be concluded that black rice has the potential to be developed as a phytopharmaceutical source of antioxidants, especially through the utilization of the ethyl acetate fraction, and the results of this study are expected to provide scientific contributions to the development of plant-based traditional medicines while encouraging the utilization of local natural resources.

Nola Rahmadasmi, Miftahul jannah · 2025 · Skripsi · Fakultas Ilmu Kesehatan, S1 Farmasi

Kulit wajah merupakan bagian yang sangat sering terpapar radikal bebas seperti asap rokok, asap kendaraan, debu, dan sinar UV. Polusi tersebut dapat menurunkan fungsi kolagen untuk mempertahankan struktur kulit sehingga dapat menyebabkan kulit wajah menjadi kusam,menggelap dan munculnya penuaan dini. Maka dari itu perlu menjaga kebersihan wajah dengan mencuci wajah secara teratur, salah satu produk yang digunakan yaitu facial wash bahan alam seperti sari buah pepaya (Carica papaya L.) kombinasi sari lidah buaya (Aloe vera Linn.) dipercayai sebagai antioksidan serta pelembab. Metode yang digunakan eksperimental dengan pengujian determinasi, preparasi, pembuatan facial wash gel dan evaluasi mutu fisik, terdapat 12 formulasi, F0 (basis), F1, F2 dan F3 (sari pepaya 5%, 10%, 15%), F4, F5 dan F6 (sari lidah buaya 5%, 10%, 15%) serta F7, F8, F9, F10 dan F11 (kombinasi sari pepaya dan sari lidah buaya 2,5:2,5 ; 5:5 ; 7,5:7,5 ; 10:5 dan 5:10). Evaluasi yang dilakukan meliputi pengujian organoleptis, homogenitas, pH, daya sebar, daya busa, viskositas dan pengujian stabilitas. Hasil penelitian menunjukkan bahwa kedua belas formulasi yang mengandung zat aktif memenuhi semua syarat evaluasi sediaan. Namun pada uji stabilitas freeze and thaw formulasi facial wash gel yang mengandung zat aktif sari buah pepaya mengalami perubahan warna dan viskositas secara signifikan dengan p-value Abstract (EN): Facial skin is one of the body parts most frequently exposed to free radicals such as cigarette smoke, vehicle emissions, dust, and UV rays. These pollutants can impair collagen function in maintaining skin structure, leading to dullness, darkening, and premature aging. Therefore, it is important to maintain facial hygiene by regularly washing the face. One product that can be used is a natural-ingredient facial wash, such as a formulation containing papaya fruit extract (Carica papaya L.) combined with aloe vera extract (Aloe vera Linn.), both known for their antioxidant and moisturizing properties. This study used an experimental method involving determination tests, preparation, formulation of facial wash gel, and evaluation of its physical quality. Twelve formulations were made: F0 (base only), F1, F2, and F3 (5%, 10%, 15% papaya extract); F4, F5, and F6 (5%, 10%, 15% aloe vera extract); and F7, F8, F9, F10, F11 (combinations of papaya and aloe vera extracts in ratios of 2.5:2.5; 5:5; 7.5:7.5; 10:5; and 5:10). The evaluations included organoleptic properties, homogeneity, pH, spreadability, foaming ability, viscosity, and stability testing. The results showed that all twelve formulations containing active ingredients met the standard evaluation criteria. However, in the freeze- thaw stability test, the facial wash gel formulations containing papaya extract showed significant changes in color and viscosity (p-value< 0.05), and significant pH changes were also observed at room temperature (p-value < 0.05). Based on the physical evaluation results, the most stable facial wash gel formulation throughout the testing period was F8 (a combination of 5% papaya extract and 5% aloe vera extract).

Nola Rahmadasmi, Miftahul jannah · 2025 · Skripsi · Fakultas Ilmu Kesehatan, S1 Farmasi

Berbagai faktor lingkungan seperti sinar matahari, radiasi, polusi udara, debu, dan asap rokok dapat memicu gangguan pada kondisi kulit, seperti kulit kering dan berjerawat. Salah satu solusi perawatan kulit adalah penggunaan gel moisturizer berbahan alami, seperti sari buah stroberi yang dikombinasikan dengan sari buah nanas. Kedua buah ini diketahui mengandung antioksidan, antiinflamasi, dan antibakteri yang dapat membantu melembapkan kulit serta meredakan jerawat. Penelitian ini bertujuan untuk mengetahui apakah kombinasi sari buah stroberi dan nanas dapat diformulasikan menjadi sediaan gel yang memenuhi standar mutu fisik yang baik, serta menilai tingkat kesukaan terhadap gel tersebut berdasarkan parameter aroma, rasa di kulit, tekstur, dan warna. Metode penelitian mencakup determinasi bahan, preparasi, ekstraksi sari buah, formulasi gel dengan berbagai konsentrasi, serta evaluasi mutu fisik. Terdapat sembilan formulasi: F0 (basis), F1–F2 (stroberi 15% dan 20%), F3–F4 (nanas 15% dan 20%), F5 (stroberi 15% + nanas 15%), F6 (stroberi 20% + nanas 20%), F7 (stroberi 7,5% + nanas 7,5%), dan F8 (stroberi 10% + nanas 10%). Evaluasi meliputi uji organoleptik, homogenitas, pH, viskositas, daya sebar, stabilitas fisik, uji hedonik, serta uji iritasi pada hewan uji dan sukarelawan. Hasil menunjukkan bahwa formulasi gel kombinasi stroberi dan nanas memenuhi standar mutu fisik dan tidak menimbulkan iritasi. Formula F8 memberikan hasil terbaik dibandingkan formulasi lainnya. Abstract (EN): Various environmental factors such as sunlight, radiation, air pollution, dust, and cigarette smoke can trigger skin conditions, such as dryness and acne. One skincare solution is the use of a natural-based moisturizing gel, such as a combination of strawberry juice and pineapple juice. These two fruits are known to contain antioxidants, anti-inflammatory, and antibacterial properties that help moisturize the skin and reduce acne. This study aims to determine whether a combination of strawberry and pineapple juice can be formulated into a gel preparation that meets good physical quality standards, and to assess consumer preferences based on aroma, skin feel, texture, and color. The research method includes material determination, preparation, fruit juice extraction, gel formulation with various concentrations, and evaluation of physical quality. There were nine formulations: F0 (base), F1–F2 (15% and 20% strawberry), F3–F4 (15% and 20% pineapple), F5 (15% strawberry + 15% pineapple), F6 (20% strawberry + 20% pineapple), F7 (7.5% strawberry + 7.5% pineapple), F8 (10% strawberry + 10% pineapple). Evaluations included organoleptic tests, homogeneity, pH, viscosity, spreadability, physical stability, hedonic testing, as well as irritation tests on test animals and volunteers. The results showed that the gel formulations combining strawberry and pineapple met physical quality standards and did not cause irritation. Formula F8 produced the best results compared to the other formulations.

Oryza Sativa Fitriani, Zulianty Gusmi Adela · 2025 · Skripsi · Fakultas Ilmu Kesehatan, S1 Farmasi

Asam salisilat merupakan salah satu bahan kimia obat yang sering ditambahkan didalam sediaan anti jerawat. Tujuan penelitian ini ialah untuk mengetahui kadar asam salisilat pada krim anti jerawat yang beredar di Kabupaten Sarolangun dengan metode Spektrofotometri UV-VIS. Sampel dalam penelitian ini sebanyak enam belas (16) produk krim anti jerawat yang beredar di Kabupaten Sarolangun. Teknik pengambilan sampel yang digunakan pada penelitian ini adalah Purposive sampling. Metode penelitian yang digunakan adalah uji warna dan Spektrofotometri UV-VIS. Hasil penelitian yang diperoleh dengan metode uji warna pada sampel 1, sampel 9, sampel 12, dan sampel 16 berwarna ungu. Sedangkan hasil penetapan kadar asam salisilat pada sampel 1 adalah 3,91 %; sampel 9 adalah 3,16 %; dan sampel 12 memiliki kadar tertinggi yaitu 4,50 %. Sementara itu, sampel 16 yang merupakan produk berizin BPOM memiliki kadar melebihi batas yang telah ditetapkan, yaitu 2,28 %. Maka dapat disimpulkan bahwa seluruh sampel tidak memenuhi ketentuan kadar maksimal yang ditetapkan BPOM. Abstract (EN): Salicylic acid is one of the active pharmaceutical ingredients commonly added to acne treatment formulations. The purpose of this study was to determine the salicylic acid content in acne creams circulating in Sarolangun Regency using the UV-VIS spectrophotometry method. A total of sixteen (16) acne cream products available in Sarolangun Regency were used as samples. The sampling technique applied was purposive sampling. The methods used in this research were color test and UV-VIS spectrophotometry. Based on the color test, samples 1, 9, 12, and 16 turned purple, indicating the presence of salicylic acid. The results of salicylic acid content determination were as follows: Sample 1: 3.91% Sample 9: 3.16% Sample 12 (highest concentration): 4.50% Sample 16 (a product registered with BPOM): 2.28%, which exceeds the maximum allowed limit. Conclusion: All tested samples did not meet the maximum salicylic acid content limit set by BPOM (Indonesian FDA), indicating non-compliance with regulatory standards.

Oryza Sativa Fitriani, Melysha Suci Putri · 2025 · Skripsi · Fakultas Ilmu Kesehatan, S1 Farmasi

Proses pengeringan merupakan tahap penting dalam pembuatan simplisia karena dapat memengaruhi kandungan senyawa aktif dan mutu simplisia. Penelitian ini bertujuan untuk mengetahui pengaruh variasi suhu pengeringan terhadap mutu simplisia ramuan obat tradisional Dayak penurun tekanan darah yang terdiri dari daun meniran (Phyllanthus niruri L.), daun ceplukan (Physalis angulata L.), daun kumis kucing (Orthosiphon aristatus), dan rimpang lempuyang emprit (Zingiber zerumbet L.). Simplisia dikeringkan menggunakan oven pada suhu 45°C, 50°C, dan 60°C, kemudian dilakukan uji standarisasi mutu berdasarkan parameter spesifik dan nonspesifik sesuai Farmakope Herbal Indonesia (2017) dan BPOM (2019). Hasil penelitian menunjukkan bahwa semua suhu pengeringan menghasilkan simplisia yang memenuhi syarat mutu. Suhu 50°C dan 60°C memberikan hasil optimal ditinjau dari organoleptik, susut pengeringan, kadar air, kadar sari larut, kadar abu, kadar abu tidak larut asam, cemaran logam. Analisis ANOVA menunjukkan variasi suhu berpengaruh signifikan terhadap beberapa parameter (p Abstract (EN): The drying process is a crucial stage in the preparation of simplisia (dried medicinal plant materials), as it can affect the content of active compounds and overall quality. This study aims to determine the effect of drying temperature variations on the quality of simplisia made from a traditional Dayak herbal remedy used to lower blood pressure. The formulation consists of meniran leaves (Phyllanthus niruri L.), ceplukan leaves (Physalis angulata L.), cat's whiskers leaves (Orthosiphon aristatus), and lempuyang emprit rhizome (Zingiber zerumbet L.). The simplisia was dried in an oven at temperatures of 45°C, 50°C, and 60°C, then evaluated for quality based on specific and non-specific standardization parameters according to the Indonesian Herbal Pharmacopoeia (2017) and BPOM standards (2019). Results showed that simplisia dried at all tested temperatures met quality requirements. However, drying at 50°C and 60°C provided optimal outcomes in terms of organoleptic properties, drying loss, moisture content, soluble extract content, total ash content, acid-insoluble ash, and heavy metal contamination. ANOVA analysis indicated that temperature variation had a significant effect on several parameters (p

Harry Ade Saputra, Zevyngka Ghea Salsabilla · 2025 · Skripsi · Fakultas Ilmu Kesehatan, S1 Farmasi

Nanoteknologi berperan penting dalam bidang farmasi, terutama dalam pengembangan nanopartikel logam seperti nanopartikel perak (AgNPs) yang memiliki aktivitas antibakteri, antioksidan, dan antikanker. Penelitian ini bertujuan untuk mensintesis dan mengkarakterisasi AgNPs menggunakan ekstrak etanol dan air daun Gambir (Uncaria gambir (W. Hunter) Roxb). sebagai agen bioreduktor alami serta mengevaluasi aktivitas toksisitasnya menggunakan metode Brine Shrimp Lethality Test (BSLT). Ekstraksi dilakukan dengan metode maserasi (etanol) dan infusa (air), kemudian karakterisasi dilakukan menggunakan LC-HRMS dan Particle Size Analyzer (PSA). Hasil menunjukkan bahwa AgNPs dari ekstrak etanol memiliki ukuran partikel 177 nm, zeta potensial +22,08 mV, dan PDI 0,227, menandakan kestabilan yang baik. Sedangkan ekstrak air menghasilkan partikel 1.333 nm dengan kestabilan lebih rendah. Nilai LC5 0 masing-masing adalah 4,964 μg/mL (etanol) dan 8,44 μg/mL (air), menunjukkan aktivitas toksik kuat terutama pada ekstrak etanol. Abstract (EN): Nanotechnology plays an important role in the pharmaceutical field, particularly in the development of metallic nanoparticles such as silver nanoparticles (AgNPs), which exhibit antibacterial, antioxidant, and anticancer activities. This study aimed to synthesize and characterize AgNPs using ethanolic and aqueous extracts of Uncaria gambir (W. Hunter) Roxb. leaves as natural bioreducing agents and to evaluate their toxicity using the Brine Shrimp Lethality Test (BSLT) method. The extracts were obtained through maceration (ethanol) and infusion (water) methods, then characterized using LC-HRMS and Particle Size Analyzer (PSA). The results showed that AgNPs synthesized from the ethanolic extract had a particle size of 177 nm, a zeta potential of +22.08 mV, and a PDI of 0.227, indicating good stability. Meanwhile, AgNPs from the aqueous extract had a particle size of 1,333 nm, a zeta potential of +7.92 mV, and a PDI of 0.57, indicating lower stability. The LC50 values were 4.964 μg/mL for the ethanolic extract and 8.44 μg/mL for the aqueous extract, demonstrating strong cytotoxic activity, especially in the ethanolic extract.