Search Repository Universitas Fort De Kock

Sistem imun merupakan mekanisme pertahanan alami tubuh yang kompleks dan
esensial dalam melawan berbagai antigen, termasuk virus dan bakteri. salah satu
dengan memanfaat daun alpukat (Persea americana Mill.) yang dikenal kaya akan
senyawa bioaktif seperti flavonoid dan antioksidan. Penelitian ini bertujuan untuk
melihat potensi ekstrak daun alpukat sebagai imunomodulator, dengan menguji
pengaruh terhadap profil darah lengkap dan menentukan dosis yang paling efektif.
Penelitian eksperimental ini menggunakan 16 ekor tikus putih jantan (Rattus
norvegicus) di bagi empat kelompok yaitu kontrol, dan dosis 150 mg, 300 mg, dan
600 mg per hari selama 14 hari. Pengukuran parameter meliputi kadar hemoglobin,
hematokrit, eritrosit, limfosit, monosit, dan trombosit. Hasil penelitian
menunjukkan bahwa pemberian ekstrak daun alpukat dapar meningkatkan kadar
hematokrit, eritrosit, serta trombosit. Sebaliknya, ekstrak ini tidak menunjukkan
pengaruh terhadap kadar hemoglobin, limfosit dan monosit. Secara keseluruhan,
dosis ekstrak daun alpukat sebesar 150 mg/KgBB menunjukkan hasil yang paling
optimal dalam meningkatkan profil darah lengkap sebagai imunomodulator. Studi
ini menyimpulkan bahwa ekstrak daun alpukat berpotensi sebagai bahan alami
untuk mendukung sistem imun,

The immune system is a complex and essential natural defense mechanism of
the body that fights against various antigens, including viruses and bacteria.
However, factors such as lifestyle, nutrition, and environmental exposure can
lead to a decline in immune function. Traditional medicine offers potential
alternatives to enhance immune responses, one of which is the use of avocado
leaves (Persea americana Mill.), known to be rich in bioactive compounds such
as flavonoids and antioxidants. This study aimed to assess the potential of
avocado leaf extract as an immunomodulator by evaluating its effect on the
complete blood profile and determining the most effective dosage. This
experimental study used 16 male white rats (Rattus norvegicus), divided into
four groups: a control group and three treatment groups receiving avocado leaf
extract at doses of 150 mg/kgBW, 300 mg/kgBW, and 600 mg/kgBW per day
for 14 days. Measured parameters included hemoglobin, hematocrit,
erythrocytes, lymphocytes, monocytes, and platelets. The results showed that
administration of avocado leaf extract increased hematocrit, erythrocyte, and
platelet levels. However, it did not significantly affect hemoglobin, lymphocyte,
or monocyte levels. Overall, the 150 mg/kgBW dosage showed the most
optimal results in improving the complete blood profile as an
immunomodulator. The study concludes that avocado leaf extract has potential
as a natural agent to support the immune system. However, further research is
needed, particularly on acute and chronic toxicity testing, to ensure its safety
for use.