Search Repository Universitas Fort De Kock

Daun afrika (Vernonia amygdalina Delile) merupakan salah satu tanaman herbal
yang banyak digunakan secara tradisional oleh masyarakat untuk menurunkan
kadar gula darah. Penelitian ini bertujuan untuk melihat pengaruh kombinasi
infusa daun afrika dengan glimepiride terhadap penurunan kadar gula darah pada
tikus putih jantan. Metode penelitian ini adalah experimental pre-test and post-test
control group design. Kadar gula darah hewan uji dinaikkan dengan aloksan
selama 7 hari dengan dosis 150 mg/kgBB. Sediaan infusa daun afrika dan
glimepiride diberikan secara oral selama 30 hari dengan dosis infusa daun afrika
300 mg/ 200 gramBB dan dosis glimepiride 0,036mg/200gramBB. Berdasarkan
hasil penelitian infusa positif mengandung senyawa alkaloid, flavonoid, tannin,
dan saponin yang berperan dalam penurunan kadar gula darah. Data hasil
penelitian dianalisis dengan uji statistic One Way Anova diperoleh hasil bahwa
terdapat perbedaan yang signifikan (P

African leaves (Vernonia amygdalina Delile) are a commonly used traditional
herbal remedy for lowering blood sugar levels. This study aimed to examine the
effect of combining African leaf infusion with glimepiride on blood glucose

reduction in male white rats. The research method used was an experimental pre-
test and post-test control group design. The blood glucose levels of the test

animals were elevated using alloxan at a dose of 150 mg/kgBW for seven days.
The African leaf infusion and glimepiride preparations were administered orally
for 30 days with a dose of 300 mg/200 gBW for the infusion and 0.036 mg/200
gBW for glimepiride. The phytochemical test results confirmed the presence of
alkaloids, flavonoids, tannins, and saponins in the infusion, which play a role in

lowering blood glucose levels. The data were statistically analyzed using the One-
Way ANOVA test, showing a significant difference (P