Search Repository Universitas Fort De Kock

Hiperkolesterolemia adalah keadaan yang ditandai dengan tingginya kadar
kolesterol di dalam darah. Penelitian ini bertujuan untuk melihat efektivitas fraksi
etil asetat umbi bawang dayak terhadap penurunan hiperkolesterolemia pada tikus
putih jantan. Jenis Penelitian ini adalah experimental pre-test and post-test control
group design. Kadar kolesterol hewan uji dinaikkan dengan menggunakan MLT
selama 22 hari dan sediaan fraksi bawang dayak diberikan secara oral selama 7
hari dengan dosis 100 mg/kgBB, 200 mg/kgBB, dan 400 mg/kgBB.
Senyawa yang berperan dalam penurunan kadar kolesterol yaitu antosianin
dan kuersetin dari golongan flavonoid. Data hasil penelitian dianalisis dengan uji
Statistik ONE WAY ANOVA diperoleh hasil bahwa terdapat perbedaan yang
signifikan (P

Hypercholesterolemia is a condition characterized by high levels of cholesterol
in the blood. This study aimed to assess the effectiveness of the ethyl acetate fraction
of Dayak onion bulbs in reducing hypercholesterolemia in male white rats. The
research design employed was experimental pre-test and post-test control group

design. The cholesterol levels of the test animals were increased using a high-
cholesterol diet for 22 days, and the Dayak onion bulb fraction preparations were

orally administered for 7 days at doses of 100 mg/kgBW, 200 mg/kgBW, and 400
mg/kgBW.
The compounds responsible for reducing cholesterol levels are anthocyanins
and quercetin from the flavonoid group. Data analysis using ONE WAY ANOVA
statistical test revealed significant differences (P < 0.05) in the administration of
various doses of Dayak onion bulb fractions at doses of 100 mg/kgBW, 200
mg/kgBW, and 400 mg/kgBW in reducing total cholesterol, LDL, VLDL,
triglycerides, and increasing HDL. The Dayak onion bulb fraction and simvastatin as
a comparison were effective in improving the thickness of the aortic blood vessels
and reducing foam cells due to hypercholesterolemia in rat hearts.
In conclusion, the various doses of Dayak onion bulb fractions significantly
differ in reducing hypercholesterolemia and have an effect on improving the aortic
wall and reducing foam cells.