Search Repository Universitas Fort De Kock

Dermatitis atopik merupakan penyakit dengan prevalensi yang meningkat 2-3 kali lipat pada negara maju dan berkembang selama 3 dekade terakhir. Dermatitis atopik adalah kelainan kulit kronis yang disertai inflamasi serta rasa gatal yang hebat, gejala khas pada penderita dermatitis atopik seperti kulit kering. Masyarakat provinsi Sumatera Barat, terutama di daerah Siguntur mengolah gambir secara tradisional sebagai pengobatan diare, sakit kepala, disentri, sariawan dan penyakit kulit. Tujuan penelitian ini adalah untuk melihat aktivitas antiinflamasi gel nanogambir dengan konsentrasi 1% dan 7,5% pada tikus yang diinduksi putih telur. Data dianalisis menggunakan uji one way Anova dan kruskal-wallis serta dilanjutkan uji Mann-Whitney serta Bonferroni. Pada ketebalan epidermis hasil uji one way Anova menunjukkan kelompok negatif tidak memiliki perbedaan signifikan dengan basis gel namun berbeda signifikan dengan kelompok normal, positif, gel nanogambir 1% dan 7,5%. Pada jumlah sel makrofag berdasarkan uji one way Anova menunjukkan kelompok negatif tidak berbeda nyata dengan kelompok basis gel dan gel nanogambir 1% namun berbeda nyata dengan normal, kelompok positif, gel nanogambir 7,5%. Pada jumlah sel mastosit dan kepadatan serat kolagen hasil uji kruskal-wallis dan Mann-Whitney menunjukkan kelompok negatif tidak berbeda nyata dengan basis gel namun berbeda nyata dengan kelompok normal, positif, gel nanogambir 1% dan 7,5%. Berdasarkan hasil diatas ditarik kesimpulan gel nanogambir memiliki efek sebagai antiinflamasi terhadap tikus putih jantan model dermatitis atopik.

Atopic dermatitis is a disease whose prevalence has increased 2-3 times in developed and developing countries over the last 3 decades. Atopic dermatitis is a chronic skin disorder accompanied by inflammation and intense itching, typical symptoms of atopic dermatitis sufferers such as dry skin. The people of West Sumatra province, especially in the Siguntur area, traditionally process gambier as a treatment for diarrhea, headaches, dysentery, mouth ulcers and skin diseases. The aim of this study was to examine the anti-inflammatory activity of nanogambir gel with concentrations of 1% and 7.5% in mice induced by egg white. Data were analyzed using one way Anova and Kruskal-Wallis tests and continued with the Mann-Whitney and Bonferroni tests. In terms of epidermis thickness, the results of the one way Anova test showed that the negative group did not have a significant difference with the gel base but was significantly different from the normal, positive, 1% and 7.5% nanogambir gel groups. The number of macrophage cells based on the one way Anova test showed that the negative group was not significantly different from the base gel group and 1% nanogambir gel but was significantly different from the normal, positive group, 7.5% nanogambir gel. Regarding the number of mast cells and collagen fiber density, the results of the Kruskal-Wallis and Mann-Whitney tests showed that the negative group was not significantly different from the gel base but was significantly different from the normal, positive, 1% and 7.5% nanogambir gel groups. Based on the results above, it can be concluded that nanogambir gel has an anti-inflammatory effect on male white mice with atopic dermatitis model.