Search Repository Universitas Fort De Kock

Simvastatin digunakan untuk pengobatan hiperkolesterolemia.tujuan penelitian ini yaitu membentuk multikomponen kristal simvastatin dan asam sitrat yang dapat meningkatkan kelarutan serta laju disolusi simvastatin. Multikomponen kristal dibuat dengan metode solvent drop grinding. Karakterisasi multikomponen kristal meliputi X-Ray Diffraction (XRD), Differential Scanning Calorimetry (DSC), Fourier Transform Infra-Red (FT-IR). Evaluasi multikomponen kristal yang terbentuk adalah perolehan Kembali, dan disolusi. Hasil karakterisasi dari multikomponen kristal menunjukkan tidak terdapat pola difraksi baru pada XRD, penurunan titik lebur pada DSC, pergeseran bilangan gelombang pada spektrum FT-IR. Perolehan Kembali simvastatin pada multikomponen kristal diperoleh 99,82%. Disolusi simvastatin dan multikomponen kristal dalam medium dapar fosfat pH 7,0 pada menit ke-30 69,63% dan 89,77%. Dari hasil karakterisasi dapat disimpulkan tidak terbentuknya multikomponen kristal simvastatin.

Simvastatin is used in the treatment of hypercholesterolemia. The aim of this research is to form multicomponent crystals of simvastatin and citric acid, which can enhance the solubility and dissolution rate of simvastatin. Multicomponent crystals were prepared using the solvent drop grinding method. The characterization of these multicomponent crystals included X-Ray Diffraction (XRD), Differential Scanning Calorimetry (DSC), and Fourier Transform Infrared (FT-IR) analysis. The evaluation of the formed multicomponent crystals involved the yield and dissolution rate.The results of the characterization of the multicomponent crystals showed no new diffraction patterns in the XRD analysis, a reduction in the melting point as indicated by DSC, and shifts in the wave numbers in the FT-IR spectra. A yield of 99.82% was obtained for simvastatin in the multicomponent crystals. The dissolution of simvastatin and the multicomponent crystals in a pH 7.0 phosphate buffer solution reached 69.63% and 89.77%, respectively, at the 30-minute mark. Based on the characterization results, it can be concluded that there was no formation of new crystalline phases.