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Seseorang dinyatakan hipertensi ketika tekanan darah sistolik 140 mmHg dan tekanan darah diastolik 90 mmHg bila tiga kali pemeriksaan secara terpisah. Penelitian ini bertujuan untuk mengetahui efektivitas dan melihat perbedaan penurunan pemberian ekstrak dan fraksi daun puding hitam Hitam (Graptophyllum pictum (L.) Griff) dengan captopril 0,45 mg/kgbb sebagai antihipertensi terhadap putih tikus jantan. Penelitian ini bersifat True Eksperimen dengan rancangan Pre Test Post-Test Control Design, menggunakan hewan uji tikus putih jantan yang dibagi menjadi 7 kelompok yaitu kontrol negatif, kontrol positif, pembanding (0,45 mg/kgbb) kelompok EDPH 3,6 mg/kgbb, kelompok fraksi n-heksan 3,6 mg/kgbb, fraksi etil asetat 3,6 mg/kgbb, dan fraksi etanol 3,6 mg/kgbb. Penginduksi yang digunakan adalah NaCl 8% selama 14 hari. Pengukuran tekanan darah dilakukan dengan menggunakan alat Non Invasif Blood Pressure (NIBP) CODA. Analisa data menggunakan Two Way ANOVA dilanjutkan dengan uji Duncan didapatkan hasil bahwa pemberian ekstrak dan fraksi daun puding hitam memiliki efektivitas terhadap penurunan tekanan darah sistol, diastol, arteri ratarata, dan denyut jantung secara signifikan p

Hypertension is diagnosed when systolic blood pressure is 140 mmHg and diastolic blood pressure is 90 mmHg, as determined through three separate measurements. This study seeks to assess the effectiveness and distinguish the differences in blood pressure reduction between the administration of extracts and fractions from Black Pudding Leaf (Graptophyllum pictum (L.) Griff) and captopril 0.45 mg/kgbw as an antihypertensive treatment in male Wistar white rats. The research is classified as a True Experiment, employing a Pre-Test Post-Test Control Design. Male white rats are divided into seven groups: negative control, positive control, reference (0.45 mg/kgbw), EDPH group 3.6 mg/kgbw, n-hexane fraction group 3.6 mg/kgbw, ethyl acetate fraction group 3.6 mg/kgbw, and ethanol fraction group 3.6 mg/kgbw. The inducer used is 8% NaCl for 14 days. Blood pressure measurements are conducted using the Non-Invasive Blood Pressure (NIBP) CODA device. Data analysis utilizes Two-Way Anova followed by the Duncan test, yielding significant results indicating that the administration of Black Pudding Leaf extract and fractions is effective in significantly reducing systolic and diastolic blood pressure, mean arterial pressure, and heart rate (p < 0.05). In conclusion, the most effective preparation of Black Pudding Leaf extract in reducing systolic and diastolic blood pressure, mean arterial pressure, and heart rate is the 3.6 mg/kgbw ethyl acetate fraction.