Search Repository Universitas Fort De Kock

Mikroalga Haematococcus pluvialis dapat mengakumulasi astaxantin yang merupakan pigmen merah karotenoid yang berpotensi sebagai antiinflamasi. Lotion merupakan suatu suspens, emulsi atau larutan dengan tanpa obat untuk topikal. Penelitian ini bertujuan untuk melihat aktivitas antiinflamasi pada ekstrak air mikroalga Haematococcus pluvialis yang diformulasikan dalam bentuk sediaan lotion. Uji aktivitas antiinflamasi dilakukan dengan metode HRBC (Human Red Blood Cell) menggunkan spektrofotometer panjang gelombang 420 nm, dengan kontrol positif aspirin (100 ppm 58,92), F0 ekstrak (100 ppm 55,67), F2 (100 ppm lotion 0,5g) 52,30, F3 (100 ppm lotion 0,75g) 55,11. Aktifitas antiinflamasi yang baik dimana nilai rata-rata stabilitas mendekati nilai kontrol positif aspirin. Hasil evaluasi lotion ekstrak air mikroalga Haematococcus pluvialis pada uji organoleptis FI lotion berwarna putih bentuk semi padat dan bau khas, FII berwarna abu-abu bentuk semi padat dan bau khas, FIII berwarna biru bentuk semi padat bau khas. Pada hasil uji pH, FI 6,13, FII 7,14, FIII 6,04, Uji homogenitas (FI, FII, FIII) sediaan lotion homogen, Uji viskositas FI 3167 cP, FII 2133 cP dan FIII 2850 cP. Hasil penelitian menunjukan bahwa ekstrak air mikroalga Haematococcus pluvialis berpotensi sebagai antiinflamasi yang dapat dikembangkan sebagai obat antiinflamasi dari bahan alam.

Microalgae Haematococcus pluvialis can accumulate astaxanthin, a red carotenoid pigment with the potential to serve as an anti-inflammatory agent. Lotion is a topical formulation that can be a suspension, emulsion, or solution without drugs. This research aims to investigate the anti-inflammatory activity of the water extract from microalgae Haematococcus pluvialis when formulated into a lotion. The anti-inflammatory activity was assessed using the HRBC (Human Red Blood Cell) method with a spectrophotometer at a wavelength of 420 nm, with aspirin (100 ppm) as the positive control (58.92). Results showed that F0 extract (100 ppm) had an activity of 55.67, F2 lotion (100 ppm, 0.5g) exhibited an activity of 52.30, and F3 lotion (100 ppm, 0.75g) had an activity of 55.11. These results indicate good anti-inflammatory activity, with average values approaching the positive control aspirin. The evaluation of the microalgae Haematococcus pluvialis water extract lotion included organoleptic tests, with FI lotion being semi-solid, white in color, and having a distinct odor, FII lotion being semi-solid, ash-colored, and having a unique odor, and FIII lotion being semi-solid, blue in color, and having a unique odor. In pH tests, FI had a pH of 6.13, FII had a pH of 7.14, and FIII had a pH of 6.04. Homogeneity tests revealed that all formulations (FI, FII, FIII) were homogeneous, and viscosity tests indicated that FI had a viscosity of 3167 cP, FII had a viscosity of 2133 cP, and FIII had a viscosity of 2850 cP. The research findings suggest that the water extract from microalgae Haematococcus pluvialis holds the potential to be developed into a natural anti inflammatory drug.