Search Repository Universitas Fort De Kock

Hipertensi dikenal sebagai the silent killer suatu penyakit yang tidak menular dimana hipertensi menjadi masalah kesehatan yang sangat serius. Daun matoa (Pometia Pinnata J.R Forst & G Forst) dapat mengobati hipertensi. Penelitian ini bertujuan melihat aktivitas antihipertensi dan pengaruhlama pemberian daun matoa ekstrak dan fraksi daun matoa Pometia pinnata J.R Forst & G. Forst pada tikus putih jantan (Rattus Norvegicus) galur wistar. Penelitian ini menggunakan tikus wistar jantan diinduksi hipertensi dengan MSG 100 mg selama 14 hari. Tikus dibagi menjadi 7 kelompok perkelompok 6 ekor, kelompok kontrol negatif, kelompok kontrol positif (MSG 100 mg), kelompok captopril 25 mg, dosis ekstrak 27 mg/kgbb, kelompok fraksi n-Heksana 0.86 mg/kgbb, kelompok fraksi etil asetat 1.56 mg/kgbb dan kelompok fraksi air 3.94 mg/kgbb, terapi selama 14 hari. Pengukuran tekanan darah menggunakan instrumen CODA, tekanan darah yang diukur meliputi tekanan darah sistol, diastol, arteri rata-rata dan denyut jantung. Data hasil analisa data dengan Two Way Anova dua arah dan Uji Duncan. Hasil pemberian ekstrak dan fraksi daun matoa Pometia Pinnata J.R Forst & G Forst Menunjukkan pengaruh nyata pada hasil pengukuran tekanan darah yang kurang maksimal, dengan hasil signifikan (0

Hypertension, often referred to as the "silent killer," is a non-communicable disease and a critical health issue. Matoa leaves (Pometia Pinnata J.R. Forst & G. Forst) are believed to possess anti-hypertensive properties. This study aims to assess the anti-hypertensive activity and the duration effect of administering Matoa leaf extract and fractions of Pometia Pinnata J.R. Forst & G. Forst on male white rats (Rattus Norvegicus) of the Wistar strain. The rats were induced with MSG (monosodium glutamate)-induced hypertension at a dosage of 100 mg.The rats were divided into seven groups, each comprising six individuals: a negative control group, a positive control group (MSG 100 mg), a reference group (captopril 25 mg), an extract dose group of 27 mg/kg body weight, a n-hexane fraction group of 0.86 mg/kg body weight, an ethyl acetate fraction group of 1.56 mg/kg body weight, and a water fraction group of 3.94 mg/kg body weight. The treatment lasted for 14 days. Blood pressure was measured using the CODA instrument, encompassing systolic blood pressure, diastolic blood pressure, mean arterial pressure, and heart rate.The research data were analyzed using a Two-Way Anova and Duncan's test. The results of administering Matoa leaf extract and fractions of Pometia Pinnata J.R. Forst & G. Forst demonstrated a significant effect on blood pressure measurements, albeit not as pronounced as in the reference group (captopril 25 mg). Captopril, a chemical medication widely tested in the community, has clinically proven efficacy in lowering blood pressure. Furthermore, it was observed that higher doses of Matoa leaf extract and fractions were associated with a greater percentage reduction in blood pressure.