Search Repository Universitas Fort De Kock

Aterosklerosis adalah kondisi menumpuknya plak (lemak) yang berwarna putih
atau putih kekuningan pada lapisan dalam pembuluh arteri. Umumnya pembuluh arteri yang lebih sering terkena aterosklerosis adalah pembuluh arteri utama yaitu aorta dan cabang-cabang lainnya. Aterosklerosis cenderung meningkatkan tekanan darah yang diakibatkan oleh penyempitan lumen pembuluh darah dan dapat mengurangi elastisitasnya. Meningkatnya kadar kolesterol dalam darah juga menyebabkan terjadinya penyakit stroke, karena kadar kolesterol juga berperan dalam penumpukan plak (lemak) dalam pembuluh darah, jika kolesterol meningkat maka resiko terkena aterosklerosis juga meningkat. Subjek berupa burung puyuh jantan hitam yang berumur 2-3 bulan dengan berat badan 100 g 200 g, sebanyak 30 ekor, diinduksi dengan PTU dan MLT selama 35 hari. burung puyuh jantan hitam dibagi menjadi 6 kelompok yang terdiri dari 6 ekor burung puyuh, yaitu kelompok positif, kelompok negatif, kelompok pembanding, kelompok EDM 50 mg/KgBB,
kelompok EDM 150 mg/KgBB, kelompok EDM 300 mg/KgBB. Analisa data uji statistik menggunakan One Way ANOVA. Hasil penelitian terdapat perbedaan yang signifikan dengan p value (< 0,05), antara pemberian ekstrak daun matoa terhadap penurunan kadar kolesterol total darah, LDL, HDL, VLDL, trigliserida dan histopatologi burung puyuh jantan hitam. Penurunan pada kadar kolesterol total dapat mempengaruhi gambaran histopatologis pembuluh darah aorta yaitu luas lumen pembuluh darah aorta secara signifikan (P

Atherosclerosis is a condition characterized by the accumulation of white or yellowish white plaques (fats) within the inner lining of arteries. Typically, atherosclerosis affects major arteries, including the aorta and its branches. Atherosclerosis tends to increase blood pressure due to the narrowing of blood vessel lumens and can reduce their elasticity. Elevated blood cholesterol levels also contribute to the development of stroke, as cholesterol plays a pivotal role in plaque accumulation within blood vessels. Higher cholesterol levels are associated with an increased risk of atherosclerosis. In this study, male black quails aged 2-3 months, weighing between 100g and 200g, were induced with PTU and MLT for 35 days. The quails were divided into six groups, each comprising 6 quails: a positive control group, a negative control group, a reference group, and three experimental groups treated with Matoa leaf extract (EDM) at doses of 50 mg/kgBW, 150 mg/kgBW, and 300 mg/kgBW, respectively. Statistical analysis was performed using One-Way ANOVA. The results of the study revealed a significant difference with a p value (< 0.05) in the levels of total blood cholesterol, LDL, HDL, VLDL, triglycerides, and the histopathology of the black male quail's arteries following the administration of Matoa leaf extract. The reduction in total cholesterol levels significantly affected the histopathological appearance of the aortic blood vessel lumen (P < 0.05), indicating that the administration of ethanol extract of Matoa leaves (Pometia Pinnata) can reduce total cholesterol levels and improve the aortic blood vessel lumen. In conclusion, the administration of Matoa leaf extract in male black quails can prevent the development of atherosclerosis induced by MLT + PTU. Effective dose reduction of Matoa leaf extract was observed at a dose of 50 mg/kgBW. Furthermore, the administration of Matoa leaf extract can influence the weight ratio of heart, lungs, and intestines.