Search Repository Universitas Fort De Kock

Hipertensi merupakan suatu kejadian akibat dari peningkatan tekanan darah arteri yang persisten dimana tekanan darah sistolik lebih dari 140 mmHg dari arteri diastolic lebih dari 90 mmHg. Meningkatnya jumlah obat yang tersedia, pemakaian obat serta regimen dosis obat yang lebih kompleks maka diperlukan terapi agar tidak memperparah kerusakan organ yang berakibat pada terjadinya Drug Related Problems yang mengganggu tujuan terapi pasien. Tujuan penelitian ini adalah untuk menganalisis Drug Related Problems potensial kategori ketidaksesuaian dosis dan interaksi obat pada pasien hipertensi disalah satu Puskesmas Kota Bukittinggi yang dilaksanakan bulan juni 2022.Metode penelitian ini adalah penelitian deskriptif dengan penelusuran data secara retrospektif. Data yang digunakan merupakan data rekam medik tahun 2021. Data diolah menggunakan Microsoft Excel. Sampel penelitian sebanyak 110 rekam medik pasien hipertensi yang diambil secara purposive sampling. Data interaksi obat dianalisis menggunakan Stockleys Drug Interactions 9 th edition). Sedangkan kesesuaian regimen dosis menggunakan Drug Information Handbook 21st edition AHFS (2011). Hasil penelitian menunjukan bahwa adanya ketidaksesuaian dosis obat kategori dosis kurang 6 kasus (5,45%), frekuensi rendah 5 kasus (4,55%), dan potensial interaksi obat berdasarkan mekanisme kerja farmakodinamik 2 kasus (1,81%), dan farmakokinetik 7 kasus (6,37%).Disimpulkan bahwa adanya kejadian Drug Related Problems kategori ketidaksesuaiandosis dan potensi interaksi obat pada pasienhipertensi disalah satu Puskesmas Kota Bukittinggi.

Hypertension is an event resulting from a persistent increase in arterial blood pressure where the systolic blood pressure is more than 140 mmHg from the diastolic blood pressure is more than 90 mmHg. The increase in the number of available drugs, the use of drugs and more complex drug dosage regimens require therapy so as not to aggravate organ damage resulting in Drug Related Problems that interfere the patient's therapeutic goals. The purpose of this study was to analyze the potential Drug Related Problem's category of dose mismatch and drug interactions in hypertensive patients in one of the Bukittinggi Community Health Centers which was held in June. This research method was descriptive with retrospective data searches. The data used was medical record data for 2021. The data was processed using Microsoft Excel. The research sample was 110 medical records of hypertensive patients taken by purposive sampling. Drug interaction data were analyzed using Stockley's Drug Interactions 9th edition. Meanwhile, according to the dosage regimen, using the Drug Information Handbook 21st edition and AHFS (2011). The results showed that there was a mismatch in the dose of the drug in less than 6 cases (5.45%), low frequency in 5 cases (4.55%), and potential drug interactions based on the pharmacodynamic mechanism of action in 2 cases (1.81%), and pharmacokinetics in 7 cases (6.37%). It is concluded that there are the incidence of Drug Related Problem's in the category of dose mismatch and potential drug interactions in hypertensive patients in one of the Community Health Center in Bukittinggi.