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WHO memperkirakan dari 130 juta bayi yang lahir di seluruh dunia, 4 juta meninggal pada usia neonatal dan sebagian besar (98%) trjadi di Negara berkembang ( Kemenkes RI, 2014). Data Dinas Kesehatan Provinsi Sumatra Barat bahwa AKB paling tinggi terdapat di Kota Padang yaitu sebesar 96/1000 KH. Tujuan penelitian ini untuk mengetahui Hubungan Tingkat Pengetahuan Ibu, Dukungan Keluarga dan Peran Penolong Persalinan Dengan Cakupan Imunisasi HB 0 di Puskesmas Ulak Karang Padang tahun 2018.Jenis penelitian ini adalah deskriptif analitik dengan desain cohort. Penelitian dilaksanakan bulan Januari- februari 2018 di puskesmas ulak karang kota padang dengan jumlah sampel 46 responden, cara pengambilan sampel accidental sampling. Data di peroleh dari obserfasi dengan menikuti responden, analis data dengan uji statistic chi-square. Hasil penelitian ditemukan dari 46 responden 33 responden (71,7%) memiliki Pengetahuan Tinggi, 38 responden (82,6%) ada dukungan keluarga, 32 responden (69,6%) tenaga kesehatan berperan, 17 responden (37,0%) cakupan imunisasi lengkap. Hasil analisis statistic chi-square di peroleh ada hubungan pengetahuan ( P = 000 : OR = 120,00), dukungan keluarga (P = 001 : OR = 26,250), peran penolong persalinan ( P=001 : OR =13,500). Berdasarkan hasil penelitian ketiga variable berhubungan terutama pengetahuan, pada ibu di harapkan lebih memahami tentang imunisasi HB 0, penularan HB, gejala HB , efek samping, tujuan imunisasi, manfaat imunisai. Tenaga kesehatan di harapkan meningkatkan informasi kesehatan pada responden dan masyarakat khususnya tentang imunisasi HB0.

WHO estimates that out of 130 million babies born worldwide, 4 million die at neonatal age and most (98%) occur in developing countries (Ministry of Health RI, 2014). Data from West Sumatra Provincial Health Office that the highest IMR was in Padang City as many as 96/1000 KH. The purpose of this study was to find out the relationship between mother's knowledge, family support and the role of labour care privider with coverage of HB 0 immunization at Ulak Karang community health care in Padang year 2018. This research type was analytical descriptive with cohort design. The study was conducted in January-February 2018 at Ulak Karang community health care Padang with 46 samples, accidental sampling method. Data obtained from observes by following the respondent, data analyst with chi-square statistic test. The results of the study were found from 46 respondents 37 respondents (71,7%) high knowledge, 38 respondents (82,6%) good family support, 32 respondents (69,9%) health worker role, 17 respondents (37,0% ) immunization coverage is good. The result of chi-square statistical analysis was obtained by having knowledge relation (P = 000: OR = 120,000), family support (P = 001: OR = 26,250), role of birth attendant (P = 001: OR = 13,500). Based on the results of the research, the three variables relate primarily to knowledge, to expect more understanding of immunization HB 0, HB transmission, HB symptoms, side effects, immunization objectives, immunization benefits. Health workers are expected to improve health information on the respondents and the community especially on Implementation of HB 0.