Search Repository Universitas Fort De Kock

Hypertension is a significant public health problem and is known as an
independent risk factor for cardiovascular disease. People with
hypertension also often experience complications such as hypercholesterolemia. Anti-hypertension beta-blockers are commonly used by people to treat high blood pressure and excessive heart rate. This study aims to look at the effect of bisoprolol on systolic and
diastolic blood pressure. Also, this study aims to look at the impact of
bisoprolol on the heart rate. In this study, all experimental animals
were made into hypertension first. Then the group with complications
of hypercholesterolemia was induced by feeding high fat and
propylthiouracil (PTU). Blood cholesterol levels were measured using a clinic photometer.
Systolic blood pressure, diastolic blood pressure, and heart rate were measured using noninvasive blood pressure (NIBP) blood pressure meter. Data from this study were analyzed with two-way ANOVA. The results showed that administration of bisoprolol at a dose of 2.5 mg, 5 mg, and 10 mg had a significant effect on reducing systolic blood pressure, diastolic blood pressure, and heart rate (p 0.05). The dose of 10 mg bisoprolol is the most effective
in lowering systolic blood pressure, diastolic blood pressure, and heart rate