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Statements of fact and opinion in the articles in Epidemiologic Reviews are those of the respective authors and contributors and not of Epidemiologic Reviews or Oxford University Press. Neither Oxford University Press nor Epidemiologic Reviews make any representation, express or implied, in respect of the accuracy of the material in this journal and cannot accept any legal responsibility or liability for any errors or omissions that may be made. The reader should make her or his own evaluation as to the appropriateness or otherwise of any experimental technique described.